Yes, you can disconnect email accounts and replace them by others at any time.

However, we do not recommend disconnecting accounts, but keeping them warm permanently.

Here is why:Your average response rate to sales and marketing emails is 1%. Just having to "warm up" an email account is a misperception from email marketing. Your true goal is not to warm up an email but to bring the email to a natural state by means of a natural overall average response rate. In other words, mailivery is the service that brings your total response rate (your real emails + mailivery emails) to a natural state. As soon as you deactivate mailivery, your response rate goes to abnormal again, and you land in spam more often, again.